Wegener's granulomatosis

Wegener's granulomatosis's GRANULOMATOSIS WEGENER - giant cell granulomatose-necrotizing vasculitis mainly affecting the respiratory tract, lungs and kidneys. The etiology is unknown. Provoke disease acute respiratory infections, cooling, insulation, trauma, drug intolerance, and other Systemic vasculitis, extensive granulomatous reaction type necrotizing granulomas mainly in the Airways allow you to think about leading the autoimmune mechanisms of disease. The symptoms for. The disease occurs more often in men begins with lesions of the upper respiratory tract and is manifested by a persistent runny nose with serous serous, purulent discharge, nasal bleeding, signs of infection to other parts of the upper respiratory tract, and with the involvement of the tracheobronchial tree - persistent cough with bloody purulent sputum, pain in the chest. In further developing polisindromnoe clinical picture of the disease (stage generalization), accompanied by fever, migratory polyarthritis or only arthralgia and myalgia, skin lesions (including heavy deathly-ulcerative lesions of skin), lung and other Most pathognomonic appearance pneumonectomies and ulcero-necrotic rhinitis, sinusitis, nasopharyngitis and laryngitis. In the study of lung there kiniko-x-ray symptoms of focal and confluent pneumonia with abscess formation and the formation of cavities. At this stage in the pathological process involved buds with the development of diffuse glomerulonephritis and rapidly progressive renal failure. Laboratory data is uncommon. Usually there are bright signs of inflammatory activity leukocytosis. elevated erythrocyte sedimentation rate and other Patients die of pulmonary hemorrhage or more from kidney failure. Diagnosis is difficult in the early period, and if the disease begins with pulmonary symptoms. In these patients, a biopsy of the mucous membranes of the upper respiratory tract (nasopharyngeal region) reveals granulomatous nature of the pathology. Treatment. Apply cyclophosphamide intravenously at a dose of 5 to 10 mg/kg for 2 H days with subsequent transition to the ingestion of 1 - 2 mg/kg within one month; maintenance therapy with cyclophosphamide at a dose of 25 to 50 mg daily is continued for 1 year or more. You must drink plenty of water to prevent the most serious complications of hemorrhagic cystitis. Prednisolone is prescribed in high doses to prevent the side effects of cytotoxic agents. Comments on this article yet. Be the first one! Write a comment.



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